N-(3-(2-furyl) acryloyl)-L-phenylalanyl-glycyl-glycine (FAPGG) have the maximum absorption peak at 340 nm. ACE1 catalyzes hydrolysis of FAPGG substrate to furanyl phenylalanine (FAP) and glycylglycine (GG), and the absorbance at 340 nm will be decreased. The activity of ACE1 can be calculated indirectly by measuring the decrease in absorbance at 340 nm.
N-[3-(2-furyl)acryloyl]-L-phenylalanylglycylglycine (FAPGG) have the maximum absorption peak at 340 nm, angiotensin converting enzyme catalyze N-(3[2-Furyl ]Acryloyl)-Phe-Gly-Gly to produce FAP and GG, and the absorbance at 340 nm will be decreased. The activity of ACE1 can be calculated indirectly by measuring the decrease in absorbance at 340 nm.
The principle of this kit is that ACE2 catalyzes the decomposition of substrates, releasing fluorescent products. The higher the fluorescence value, the higher the ACE2 activity in the sample. The ACE2 enzyme activity in the sample can be calculated by the standard curve.
Angiotensin converting enzyme 2 (ACE2) is an important component of the renin angiotensin system (RAS). ACE2 is a negative regulatory factor of RAS, which can balance multiple functions of ACE. By regulating angiotensin II, ACE2 can cleave angiotensin II into Ang1-7, which has active effects such as protecting the heart and relaxing blood vessels. It is also one of the key active receptors in the field of pharmaceutical science research. The principle of this kit is that ACE2 catalyzes the decomposition of substrates, releasing fluorescent products. Adding inhibitors can inhibit the fluorescence value, and the inhibition ability of inhibitors can be determined by the fluorescence value
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