Ac-ATLDALLAALRRLQ-NH2
Ac-(Nle)-EHfRWG-NH2
C47H64N14O10
Ac-Nle-OH[15891-49-3]C8H15NO3M.W. 173.2
Ac-Nva-OH[15891-50-6]C7H13NO3M.W. 159.2
Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
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