Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF85 (Zinc finger protein 85), also known as zinc finger protein HPF4 or HTF1, is a member of the ZNF91 family and is thought to be involved in transcriptional regulation. ZNF85 is highly expressed in testicular tissue and localizes to the nucleus. ZNF85 contains sixteen C2H2-type zinc fingers and one KRAB domain through which it is thought to be involved in DNA-binding and transcriptional regulation.
ZNF8 (zinc finger protein 8) is a 575 amino acid protein that belongs to the Krüppel C2H2-type zinc-finger protein family and contains seven C2H2-type zinc fingers and a KRAB domain. Localizing to the nucleus and ubiquitously expressed, ZNF8 is thought to play a role in transcriptional regulation and is encoded by a gene that maps to human chromosome 19q13.43.
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