A synthesized peptide derived from human NEDD8, corresponding to a region within the internal amino acids.
NEDD8 (neural precursor cell expressed, developmentally down-regulated 8) is a protein-coding gene. Diseases associated with NEDD8 include glomuvenous malformation. GO annotations related to this gene include ubiquitin protein ligase binding.
A synthesized peptide derived from human NEDD9, corresponding to a region within the internal amino acids.
The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants.
NEFH,also named as KIAA0845 and NFH,Belongs to the intermediate filament family. It has an important function in mature axons that is not subserved by the two smaller NF proteins. Neurofilaments are the 10nm intermediate filaments found specifically in neurons. They are a major component of the cell's cytoskeleton,and provide support for normal axonal radial growth. Neurofilaments usually contain three intermediate filament proteins: L,M,and H which are involved in the maintenance of neuronal caliber. The names given to the three major neurofilament subunits are based upon the apparent molecular weight of the mammalian subunits on SDS-PAGE:NF-L,65-68kd; NF-M,145-160kd and NF-H,200-220kd. This antibody recognize NEFH only.
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