Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks.
Neurofilaments usually contain three intermediate filament proteins: NEFL,NEFM,and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks.
A synthetic peptide from human NEFL
A synthesized peptide derived from human NEFM, corresponding to a region within the internal amino acids.
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
A synthesized peptide derived from human NEGR1, corresponding to a region within the internal amino acids.
NEGR1 (Neuronal Growth Regulator 1) is a Protein Coding gene. Diseases associated with NEGR1 include Podoconiosis. Among its related pathways are Post-translational modification- synthesis of GPI-anchored proteins and Metabolism of proteins. An important paralog of this gene is LSAMP.
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