This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes.
A synthetic peptide from human NR1D1
A synthesized peptide derived from human NR1D2, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human NR1H2, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human NR1H3, corresponding to a region within C-terminal amino acids.
A synthetic peptide from human NR1H3
A synthesized peptide derived from human NR1H4, corresponding to a region within N-terminal amino acids.
A synthesized peptide derived from human NR1I2, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human NR1I3, corresponding to a region within the internal amino acids.
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.
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