This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene.
A synthesized peptide derived from human NR2C1, corresponding to a region within N-terminal amino acids.
A synthesized peptide derived from human NR2C2, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human NR2E1, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human NR2E3, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human NR2F1.
This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants.
A synthesized peptide derived from human NR2F6, corresponding to a region within N-terminal amino acids.
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