A synthesized peptide derived from human PCSK9, corresponding to a region within the internal amino acids.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a crucial protein governing the circulating levels of low density lipoprotein-cholesterol (LDL-C), by virtue of its pivotal role in the degradation of the LDL receptor (LDLR). PCSK9 is expressed in the kidney and lung. It is synthesized as a 72 kDa immature precursor that undergoes autocatalytic cleavage in the endoplasmic reticulum to generate a 63 kDa mature protein. The cleaved N-terminal fragment remains associated with the mature protein and is necessary for its secretion, allowing it to circulate in the blood. The ability of PCSK9 to regulate a diverse group of cell-surface proteins hinted that it might also be able to influence additional membrane proteins that are important in anti-tumour immune responses. Targeting PCSK9 to treat cancer is also attractive because two neutralizing antibodies against it, evolocumab and alirocumab, have already been approved for human clinical use to lower cholesterol levels.
A synthetic peptide from human PCSK9
A synthesized peptide derived from human PCTK1, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human PCTK2, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human PCTK3, corresponding to a region within C-terminal amino acids.
Procalcitonin (PCT) is the peptide precursor of calcitonin, a hormone that is synthesized by the parafollicular C cells of the thyroid. The serum concentration of PCT increases rapidly in patients with systemic nonviral infections. Therefore, PCT is a hig
A synthesized peptide derived from human PCYOX1, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human PCYT1A, corresponding to a region within C-terminal amino acids.
This gene encodes an enzyme that catalyzes the formation of CDP-ethanolamine from CTP and phosphoethanolamine in the Kennedy pathway of phospholipid synthesis. Alternative splicing results in multiple transcript variants.
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