Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms.
A synthesized peptide derived from human PDIA6, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human PDI, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human PDIK1L, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human PDK2, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human PDK3.
A synthesized peptide derived from human PDK4, corresponding to a region within C-terminal amino acids.
This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin.
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