This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.
A synthetic peptide from mouse PD-L1
A synthetic peptide from human PD-L1
A synthesized peptide derived from human PDLIM1, corresponding to a region within the internal amino acids.
A synthesized peptide derived from Human PDLIM2.
A synthesized peptide derived from human ALP, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human PDLIM4.
This gene encodes a protein which may be involved in bone development. Mutations in this gene are associated with susceptibility to osteoporosis.
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