RHO GTPases (see ARHA; MIM 165390) regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15 (Seoh et al., 2003 [PubMed 12650940]). GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.
RHO GTPases regulate diverse biologic processes, and their activity is regulated by RHO GTPase-activating proteins (GAPs), such as ARHGAP15. GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction.
A synthesized peptide derived from human ARHGAP1, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human ARHGAP22, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human ARHGAP25, corresponding to a region within the internal amino acids.
Rho GTPase activating protein 25is aproteinthat in humans is encoded by theARHGAP25gene. The gene is also known asKAIA0053. ARHGAP25 belongs to a family ofRho GTPase-modulating proteins which are implicated inactinremodeling,cell polarity, andcell migration. GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
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