The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. Three transcript variants encoding two different isoforms have been found for this gene.
A synthesized peptide derived from human BAGE2, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human BAGE5, corresponding to a region within N-terminal amino acids.
A synthesized peptide derived from human BAHD1.
A synthesized peptide derived from human BAI1, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human BAI2, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human BAI3, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human BAIAP2.
A synthesized peptide derived from human BAIAP2L1, corresponding to a region within the internal amino acids.
This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation.
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