The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
A synthesized peptide derived from human Bak, corresponding to a region within N-terminal amino acids.
A synthetic peptide from human Bak
A synthesized peptide derived from human Bamacan, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human BAMBI, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human Band 3/AE 1, corresponding to a region within the internal amino acids.
A synthesized peptide derived from Human BANF1.
A synthesized peptide derived from human BANP, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human BAP1, corresponding to a region within the internal amino acids.
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma.
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