This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
A synthetic peptide from human BRCA1
A synthesized peptide derived from human BRCA2, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human BRCA2.
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.
A synthetic peptide from human BRCA2
A synthesized peptide derived from human BRCAA1, corresponding to a region within C-terminal amino acids.
A synthesized peptide derived from human BRCC3, corresponding to a region within the internal amino acids.
A synthesized peptide derived from Human BRD1.
A synthesized peptide derived from human BRD2, corresponding to a region within N-terminal amino acids.
A synthesized peptide derived from human BRD3, corresponding to a region within C-terminal amino acids.
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