The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with an hyper-IgM syndrome.
Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid; erythroid; and lymphoid progenitors in bone marrow cultures and has been shown to act synergistically with colony stimulating factors.
Similar to Kit ligand precursor (C-kit ligand) , also known as Stem cell factor (SCF) , Mast cell growth factor (MGF) , or Hematopoietic growth factor KL. SCF/C-kit ligand is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development , and hematopoiesis , all believed to reflect a role in cell migration. In adults , it functions pleiotropically , while mostly noted for its continued requirement in hematopoiesis. SCF/C-kit ligand stimulates the proliferation of mast cells. This protein can augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. It may act synergistically with other cytokines , probably interleukins SCF/C-kit ligand is the ligand for the tyrosine kinase receptor c-kit , which is expressed on both primitive and mature hematopoietic progenitor cells. In vitro , SCF/C-kit ligand synergizes with other growth factors , such as granulocyte colony-stimulating factor (G-CSF) , granulocyte-macrophage colony-stimulating factor , and interleukin-3 to stimulate the proliferation and differentiation of cells of the lymphoid , myeloid , erythroid , and megakaryocytic lineages. In vivo , SCF/C-kit also synergizes with other growth factors and has been shown to enhance the mobilization of peripheral blood progenitor cells in combination with G-CSF. In phase I/II clinical studies administration of the combination of SCF and G-CSF resulted in a two-to threefold increase in cells that express the CD34 antigen compared with G-CSF alone.
This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene.
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