Sec13 is a ubiquitously expressed protein which participates in the formation of vesicles in the COPII complex with Sec23p.Sec24p, Sar1p and Sec31. The COPII vesicle budding complex was first described in the yeast system and was shown to provide coat proteins in the early secretory pathway. Sec13 is recruited to endoplasmic reticulum (ER) membranes where it forms a three dimensional cuboctahedron cage lattice structure by association with Sec31. This vesicular structure is necessary for ER-Golgi transport.
Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
Secretogranin-2 is also known as Chromogranin-C,Secretogranin II, SgII. In humans, it is encoded by the SCG2 gene.It belongs to the chromogranin/secretogranin protein family. Secretogranin-2 is a neuroendocrine secretory granule protein, which is the precursor for biologically active peptides. It derived secretoneurin was distributed with strong immunoreactivity in the somata of pelvic ganglion neurons,72% of which also contained tyrosine hydroxyldse,as well as in nerve terminals in the muscular layer and the lamina propria of the vas deferens.
Secretogranin-3(SCG3) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. SCG3 is expressed in brain, heart, kidney, liver and skeletal muscle. It may serve as precursors for biologically active peptides. Some granins have been shown to function as helper proteins in sorting and proteolytic processing of prohormones, however, the function of this protein is unknown.
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