The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found.
A synthesized peptide derived from human NCK2, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human NCKAP1, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human NCKAP1L.
A synthesized peptide derived from human NCKIPSD, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human NCoA2, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human NCOA4, corresponding to a region within C-terminal amino acids.
This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14.
A synthesized peptide derived from human NCOA5, corresponding to a region within N-terminal amino acids.
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