Natural cytotoxicity triggering receptor 1is aproteinthat in humans is encoded by theNCR1gene. NCR1 has also been designated asCD335(cluster of differentiation335). Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Interacts with CD247 and FCER1G. Selectively expressed by both resting and activated NK cells.
A synthesized peptide derived from human NCR2, corresponding to a region within the internal amino acids.
Natural cytotoxicity triggering receptor 2is aproteinthat in humans is encoded by theNCR2gene. NCR2 has also been designated asCD336(cluster of differentiation336). NKp44 is a natural cytotoxicity receptor that is is expressed on IL-2-activated human NK cells and may contribute to the increased efficiency of NK cells to mediate tumor cell lysis. NKp44 is composed of one Ig-like extracellular domain, a transmembrane segment, and a cytoplasmic domain. Prolactin up-regulates and cortisol down-regulates the surface expression of NKp44 at the transcriptional level. A cellular ligand for NKp44 (NKp44L) is expressed during HIV-1 infection and is correlated with the progression of CD4+ T cell depletion and an increase of viral load.
A synthesized peptide derived from human NCR3, corresponding to a region within the internal amino acids.
The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.
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