A synthesized peptide derived from human p130 Cas, corresponding to a region within N-terminal amino acids.
A synthesized peptide derived from human p130 Cas, corresponding to a region within the internal amino acids.
A synthetic peptide from human p130 Cas
A synthesized peptide derived from human p14 ARF, corresponding to a region within the internal amino acids.
A synthesized peptide derived from human p15 INK4b, corresponding to a region within the internal amino acids.
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53.
Inserisci la tua e-mail e seleziona le aree di interesse per ricevere le ultime novità, approfondimenti e promozioni.
Seleziona uno o più ambiti di interesse per ricevere comunicazioni più utili e mirate.
2025 TEMA Ricerca - All Rights Reserved.
